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Dihexa is metabolised primarily by CYP3A4 enzymes, which oxidise the compound into inactive metabolites, and by UDP-glucuronosyltransferases, which conjugate it with glucuronic acid for renal excretion

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Therefore, the increased susceptibility to H 2 O 2 -induced cell death in macrophages from individual with CD seen in this study may be due to their derivation from the CD16 + monocyte population with decreased GPx1 expression